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Endoplasmic reticulum (ER) membrane #1

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opened 2025-03-15 22:05:44 +00:00 by solana · 0 comments
solana commented 2025-03-15 22:05:44 +00:00
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We are interested in the molecular mechanisms by which proteins are transported across membranes. In the past, we have focused on how proteins are translocated across the endoplasmic reticulum (ER) membrane. We showed that they are transported through a protein-conducting channel, formed from a conserved heterotrimeric membrane protein complex, called the Sec61 complex in eukaryotes, and the SecY complex in prokaryotes. The channel is a passive pore that needs to associate with partners that provide a driving force for translocation. We have solved the Xray structure of the resting channel and the structure of bacterial channels that contain a translocating polypeptide chain. We have studied the mechanisms by which proteins are translocated co- or post-translationally through the Sec61/SecY channel.

We are interested in the molecular mechanisms by which proteins are transported across membranes. In the past, we have focused on how proteins are translocated across the endoplasmic reticulum (ER) membrane. We showed that they are transported through a protein-conducting channel, formed from a conserved heterotrimeric membrane protein complex, called the Sec61 complex in eukaryotes, and the SecY complex in prokaryotes. The channel is a passive pore that needs to associate with partners that provide a driving force for translocation. We have solved the Xray structure of the resting channel and the structure of bacterial channels that contain a translocating polypeptide chain. We have studied the mechanisms by which proteins are translocated co- or post-translationally through the Sec61/SecY channel.
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